The lyophilised vial contains: Sodium succinate, methylprednisolone equivalent to 125 and 500 mg methylprednisolone Pharmacodynamics: Methylprednisolone is a potent anti-inflammatory steroid, prednisolone greater than and less tendency to retain water and sodium than the same prednisolone. Methylprednisolone sodium succinate has the same metabolic and anti-inflammatory actions methylprednisolone. When applied parenterally and in equimolar amounts, the two components are equivalent in biological activity. The relative potency of SOLU-MEDROL and hydrocortisone sodium succinate depression eosinophil count, after IV administration, is at least 4: 1 This is consistent with the relative potency of methylprednisolone and hydrocortisone VO Pharmacokinetics of methylprednisolone plasma concentrations were measured by an HPLC assay. After 40 mg dose I.M. methylprednisolone sodium succinate were administered to 14 healthy male adult volunteers, the mean peak concentration of 454 ng / ml was reached within an hour. In 12 hours, the plasma concentration of methylprednisolone has declined to 31.9 ng / ml. Methylprednisolone was not detectable 18 hours after dosing. Based on the area under the concentration time curve, an indication of the total drug absorbed IM methylprednisolone sodium succinate equivalent was found at the same dose administered intravenously. Results of one study showed that the succinate ester of methylprednisolone is rapidly and extensively changed to half the assets of methylprednisolone after all routes of administration. The extent of absorption of free methylprednisolone IV followed by administering and I. M. was found to be equivalent and significantly larger in quantity hemisuccinate ester reached the general circulation after IV administration Apparently the hemisuccinate ester is converted to the tissue after intramuscular injection with subsequent absorption as free methylprednisolone
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