Trivafluc Azithromycin fluconazole tinidazo 250/37.5/500mg 4tabs


rn Please consult your physician before taking any medication. Each tablet contains: Tinidazole 500 mg, Azithromycin dihydrate equivalent to 250 mg azithromycin, 37.5 mg fluconazole. INDICATIONS: Indicated both men and women in uncomplicated genital infections caused by Candida spp, Chlamydia trachomatis, Haemophilus ducreyi, Neisseria gonorrhoeae, Trichomonas vaginalis, Treponema pallidum, Gardnerella vaginalis. Pharmacokinetics: Following oral administration in humans , azithromycin is widely distributed throughout the body . Its bioavailability is about 37 % . Administration after a hearty meal decreases its bioavailability by approximately 50%. The time required to reach peak plasma levels is 2-3 hours. Distribution: In animal studies, there have been high concentrations of azithromycin in phagocytes. In animal models, this results in the release of high concentrations of azithromycin at the infection site. Pharmacokinetic studies in humans have shown much higher levels of azithromycin in tissues than in plasma (up to 50 times the maximum observed plasma concentration) indicating that the drug binds strongly to tissue. Elimination The terminal elimination half-life of the average life closely reflects tissue depletion of 2 to 4 days. Tinidazole : Pharmacokinetics of tinidazole is similar to that of metronidazole ; however, the half life is greater tinidazole . Absorption Tinidazole is almost completely absorbed when administered orally, presenting a peak in the plasma concentration of about 40 .mu.g / ml during the first 2 hours after administration of a single dose of 2 g , decreasing about 10 ug / ml at 24 hours and 2.5 g / ml at 48 hours . You can maintain concentrations above 8 ug / ml to administer a dose of 1 g (two tablets ) daily. Distribution: Tinidazole is widely distributed and found similar plasma concentrations in bile, breast milk, cerebrospinal fluid , saliva and a variety of body tissues ; the drug crosses the placenta rapidly. It has been reported that nearly 12 % is bound to plasma proteins. Elimination: The plasma elimination half-life of tinidazole is 12 to 14 hours, identifying an active hydroxylated metabolite. The drug and its metabolites are primarily excreted in the urine and to a lesser extent in the feces. Fluconazole belongs to a new class of antifungals, the triazoles , which inhibit the synthesis of sterols in fungi. Administered orally, is well absorbed but absorption is not affected by food; bioavailability is greater than 90 %. Peak plasma concentrations are achieved fasting between 30 and 90 minutes, with a plasma elimination half-life of 30 hours, with concentrations proportional to dose. Ninety percent of the stable serum levels are reached about 4 °. Or 5th. Day of its daily administration. Its protein binding is 11-12 %. Fluconazole adequately penetrates all body fluids, achieving concentrations in saliva and sputum similar to plasma: CSF achieved in 80 % of plasma concentrations achieved. Fluconazole achieves higher serum concentrations in stratum corneum , skin and sweat glands. The main route of elimination is renal, recovering about 80 % of the administered dose as unchanged drug, with debugging proportional to creatinine clearance fluconazole. The long plasma elimination half-life provides the basis for the treatment of vaginal candidiasis.

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