Prednisone is a glucocorticosteroid that is prescribed to treat systemic connective tissue diseases. The drug is effective for acute and chronic pathologies of joints, skin, eyes, blood and circulatory system, lung diseases, hepatitis, and other diseases. Characterized by anti-inflammatory, anti-allergic, immunosuppressive, antishock effects.
The active ingredient blocks the synthesis of prostaglandin, thus stopping the development of an inflammatory reaction. Reduces the release of cytotoxic lysosomal enzymes. It’s used for internal administration. It is well absorbed from the gastrointestinal tract. The concentration in the blood reaches its maximum value after 90 minutes. Semi elimination after 200 minutes after intake. Metabolism occurs in the liver. 20% of Prednisone is excreted by the kidneys unchanged.
- Systemic lupus erythematosus, scleroderma, periarteritis nodosa, dermatomyositis, rheumatoid arthritis.
- Arthritis, polyarthritis, osteoarthritis, and other inflammatory processes in the joints.
- The acute course of rheumatism and rheumatic heart disease.
- Various manifestations of allergic reactions.
- Atopic, contact dermatitis, eczema, psoriasis, and other skin diseases.
- Allergic and inflammatory eye pathologies.
- Pathologies of the blood and circulatory system.
- Interstitial pathologies of the lungs.
The dose of Prednisone is prescribed individually. When selecting the dosage, the physiological fluctuation of glucocorticosteroids is taken into account. Large doses are prescribed in the morning, at lunchtime the dosage is reduced, in the evening reception of the minimum amount of the drug is prescribed. It’s recommended to take a daily dose in one or two doses of 6-8 a.m. after breakfast.
In the acute course of pathologies, treatment begins with a dose of 20-30 mg per day. To maintain the condition, 5-10 mg is prescribed. The dose of the drug is 1-2 mg/kg. Higher doses are prescribed for leukemia, neurotic syndrome, rheumatic pathologies. The drug should be withdrawn gradually, reducing the dose several times. The duration of treatment depends on the severity of the patient's condition.
- Individual intolerance of individual components of the drug.
- Systemic fungal lesions.
- Peptic ulcer and 12 duodenal ulcer.
- Systemic osteoporosis.
- Cushing's syndrome.
- Proclivity to thromboembolic pathology.
- Renal insufficiency.
- Severe arterial hypertension.
- Chickenpox, herpes simplex.
- Active tuberculosis.
Administration of glucocorticosteroids during pregnancy is dangerous because of the embryotoxic effect. Benefits and harms to the fetus are carefully weighed. Breastfeeding should be stopped while you are taking them.
Depending on the condition, Prednisone may cause a decrease in the body's strength. Adverse reactions include increased blood pressure, increased protein catabolism. The drug can lead to adrenal atrophy, edema, and elevated sugar levels. The drug provokes insomnia, a violation of the menstrual cycle. In some cases, the drug causes developmental delays in children. Adverse reactions include Cushing's syndrome, increased acidity of gastric juice, ulceration of the mucous membrane of the gastrointestinal tract. Adverse reactions are intensified in case of overdose. Symptomatic treatment is carried out to eliminate the reaction. The drug shouldn’t be combined with barbiturates.