Cymbalta duloxetine


The drug Cymbalta, also known as duloxetine, is an antidepressant used in medical practice to treat a number of conditions. This medication belongs to the serotonin-norepinephrine reuptake inhibitor (SNRI) class and is used to treat a wide range of conditions, including depression, generalized anxiety, diabetic neuropathy, and fibromyalgia.


The half-life of Cymbalta is approximately 12 hours, which means that half of a dose of the drug is eliminated from the body in about 12 hours after it is taken.

How long does it take for Cymbalta to work?

The effects of Cymbalta can last for several hours after a dose, and stabilization of the condition is usually seen after several weeks of regular use.

How it is excreted from the body?

Cymbalta is excreted from the body mainly through the kidneys. Patients with impaired kidney function should be under strict medical supervision while taking this medication.

Cymbalta (duloxetine) - Dosage

The dosage of Cymbalta (duloxetine) depends on the specific disease and the patient's individual response. Treatment begins with taking the minimum dose to minimize side effects, after which the dose can be gradually increased. The drug is taken once a day, preferably with food. It is important to take the medication regularly, at the same time each day, to maintain a stable level of duloxetine in the body. You should not stop taking Cymbalta suddenly, as this can cause withdrawal symptoms. If it is decided to discontinue the drug, your doctor will develop a plan to gradually reduce the dosage to minimize unwanted withdrawal effects.

Cymbalta: Overdose

Cymbalta overdose can be dangerous and requires immediate medical attention. Symptoms may include nausea, vomiting, seizures, dizziness, changes in consciousness, and tachycardia.


Contraindications to taking Cymbalta include individual intolerance to duloxetine, concurrent use of monoamine oxidase inhibitors (MAOIs), and certain other conditions. The doctor should be aware of all existing medical conditions and medications taken by the patient.

Side effects

Cymbalta side effects may include nausea, dry mouth, fatigue, headaches, insomnia, and others. Some of these effects may decrease over time with continued use of the drug.

Interactions with other medications

The interaction of Cymbalta (duloxetine) with other drugs is an important aspect of pharmacotherapy that requires careful study and understanding by both physicians and patients. Cymbalta, as a selective serotonin and norepinephrine reuptake inhibitor (SSRI), has the potential for interactions with a wide range of drugs, which may affect its efficacy and safety.

Antidepressants: Particular attention should be paid to the combination of Cymbalta with other antidepressants, especially monoamine oxidase inhibitors (MAOIs) and other SSRIs. Such a combination can lead to serotonin syndrome, a dangerous condition characterized by high body temperature, tremors, increased sweating, diarrhea, and hyperexcitability.

Antihypertensive: Cymbalta may increase the hypotensive effect of antihypertensive drugs. This may result in excessive lowering of blood pressure, dizziness and fainting, especially when rising from a lying or sitting position (orthostatic hypotension).

Anticonvulsants: Agents such as carbamazepine and phenytoin may accelerate the metabolism of duloxetine, potentially reducing its efficacy. In such cases, Cymbalta dose adjustment may be required.

Anticoagulants: Cymbalta may increase the effects of anticoagulants and drugs that prevent thrombosis, such as warfarin and aspirin. This increases the risk of bleeding, especially if the patient has other risk factors.

NSAIDs: Taking Cymbalta and nonsteroidal anti-inflammatory drugs (NSAIDs) at the same time increases the risk of gastrointestinal bleeding.

Benzodiazepines: Co-administration of Cymbalta with benzodiazepines, such as diazepam or alprazolam, may increase their sedative and myorelaxant effects. This increases the risk of drowsiness and impaired coordination of movements, which may be particularly dangerous when driving or operating machinery.

Nutritional supplements: Some herbal remedies and nutritional supplements, such as St. John's wort, may interact with Cymbalta, altering its metabolism and efficacy. It is important to consult your doctor before adding such remedies to your treatment regimen.

Opioids: Combining Cymbalta with opioid analgesics may increase the risk of serotonin syndrome and increase the likelihood of opioid dependence.

Anti-migraine: Triptans used to treat migraines may increase the risk of serotonin syndrome when taken together with Cymbalta. Symptoms should be monitored closely and dosage adjusted if necessary.

Cymbalta for anxiety

Cymbalta is often used to treat generalized anxiety disorder. The drug's effectiveness in this case is due to its ability to affect serotonin and norepinephrine levels in the brain, which helps reduce symptoms of anxiety.

Cymbalta and alcohol

Combining Cymbalta and alcohol can increase the side effects of both alcohol and duloxetine, especially in terms of impaired coordination and judgment. Doctors generally recommend avoiding alcohol during treatment with Cymbalta.

Cymbalta and weight loss

Weight loss can be a side effect of taking Cymbalta. Although this is not always the desired outcome, some patients report moderate weight loss at the beginning of treatment.

Cymbalta for neuropathy

Cymbalta is used to treat a wide range of pain syndromes, including diabetic neuropathy. The drug helps reduce neuropathic pain by affecting the chemical processes in the brain associated with pain.

Cymbalta and pregnancy

The use of Cymbalta during pregnancy requires caution. The potential risks and benefits of taking this drug should be carefully weighed, especially during the first trimester of pregnancy.

Cymbalta and Adderall

Combining Cymbalta and Adderall may increase the risk of serious side effects such as heart abnormalities or high blood pressure. It is important that your doctor monitor your patient's condition when taking these medications at the same time.

Cymbalta and insomnia

Insomnia is one of the possible side effects of taking Cymbalta. In some cases, doctors may recommend taking the drug in the morning to minimize the effects on sleep.

Cymbalta and ADHD

Although Cymbalta is not approved for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), it is sometimes prescribed as an adjunctive therapy to manage some of the symptoms of ADHD, especially if they are accompanied by depression or an anxiety disorder.

In conclusion, Cymbalta (duloxetine) is a multifunctional antidepressant that can be effective in treating a wide range of conditions. However, like any other medication, it requires careful prescribing and monitoring by a physician, especially considering possible side effects and interactions with other medications.

The drug's effectiveness is due to its ability to affect serotonin and norepinephrine levels in the brain, which helps reduce symptoms of anxiety. Additional treatments, such as psychotherapy, exercise or relaxation techniques, may also be prescribed to enhance the effectiveness of the therapy.

Quantity in a package
Generic 60 mg 14 tabs Delayed-release, 60 mg 28 caps, Generic 30 mg 7 tabs Delayed-release
Reviews Cymbalta duloxetine
Cymbalta helped manage my depression and anxiety symptoms. Noticed a positive change in mood and energy. It\'s been a crucial part of my mental health treatment. Remember to consult with a doctor for best results.
Maria C.
Started Cymbalta for chronic nerve pain and it\'s been effective. It took a few weeks to see improvements, but my pain levels have significantly decreased.

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