rn Please consult your physician before taking any medication. Cymbalta 60mg 28 Caps Generic Name: duloxetine (du LOX e teen) Brand Names: Cymbalta What is duloxetine? Duloxetine is an antidepressant in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Duloxetine affects chemicals in the brain that may become unbalanced and cause depression. Duloxetine is used to treat major depressive disorder and general anxiety disorder. It is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy). Duloxetine may also be used for purposes other than those listed in this medication guide.